A systematic review (SR) is a review of a clearly formulated question that uses systematic and reproducible methods to identify, select and critically appraise all relevant research, and to collect and analyse data from the studies that are included in the review. Systematic Review is the highest point of the evidence pyramid but many authors are frightened by its complexity. We explain step by step how to perform a SR in a practical and simple way. Don’t miss this UrologyCheatSheet!